by Patriots staff
A federal judge recently ordered the release of the Affidavit behind the raid at Trump's residence in Mar-a-Largo. As expected it was too heavily redacted including the reasons for the raid which begs the question why release anything but a blank piece of paper? How's that for in your face? DOJ, FBI ‘So Corrupt that They're Redacting their Reasons for Redactions’ in Released Affidavit, ‘Federalist’ CEO Mocks
An FBI agent has already pled guilty to destroying exculpatory evidence to frame a pro-Trump political prisoner demonstrating they are willing to do what it takes to advance the deep state agenda. There is further evidence that the FBI interfered with the 2020 election by pressuring Facebook to suppress the Hunter Biden Laptop story. Isn't this what banana republics and totalitarian regimes do?
How many more abuses will occur before this message gets across to the lame brains that inhabit Congress? Do you enjoy being spied on by the deep state uniparty ruling Hunta? The FBI is an out-of-control rogue agency that doesn't work for anything more that the administrative state's desire to intimidate and suppress truth.When will our 'so-called' Congress deal with reality rather than the endless psychoses that they live out each and every day?
Obviously Congress must have refried beans maquerading as brains in their cranial cavaties. The public had better think about where the country is headed. How many more Randy Weaver and/ or WACO incidents will there be before everyone wakes up to the realization that the FBI's charter is not to arrest criminals or stop terrorists but to neutralize political opposition to the administrative state. If they can do this to a former president, they don't like.. what will they do to regular conservatives? When the FBI raids your home as they did in Mesa County Colorado, busting in Tina Peters' front door with a battering ram and in the case of Shironna Bishop, making her sixteen-year-old daughter stand outside their home's front door in her underwear. Don't anybody give me crap about how professional this rat bin is. Cause it ain't!
Following in the footsteps of the late J. Edgar Hoover the agency very likely has real blackmail evidence on every member of Congress, including the known slimy ones. This FBI caper against the former president puts us very close to a full-blown police state. It's time for the loudmouth fools who inhabit government to start taking steps to END the FBI because the corruption is too deep to reform it.
Doing nothing will only embolden Chris Wray et All to commit greater abuses until you won't be able to end it. The TIME to act is NOW!!
HUGE: Federal Judge Begins Process to Appoint Special Master to Review Items Taken From Mar-a-Lago During Jackbooted FBI Raid
by Robert W. Chandler, M.D., M.B.A. - Team 5
At the launch of widespread mass
inoculation of the public with Pfizer’s mRNA vaccine, BNT162b2, media,
physicians’ spokespeople, and government officials communicated widely
that the injected drug would be retained at the injection site muscle
tissue and in local lymph nodes. The components were supposed to be
metabolized in a day or so, leaving only induced SARS CoV-2 Spike
antigen to evoke a therapeutic immune response. A short pulse of drug
effect would be followed, they claimed, by limited production of Spike
antigen.
However, newly released internal
Pfizer documents show that this is not true. In fact, the injection
causes widespread distribution of the material in tissues and this
distribution persists for at least two days, and probably much longer.
These facts are the exact opposite of what was publicized.
A cluster of FDA-released Pfizer documents — “Final
Report: A Tissue Distribution Study of a [3H]-Labelled Lipid
Nanoparticle-mRNA Formulation Containing ALC-0315 and ALC-0159 Following
Intramuscular Administration in Wistar Han Rats”[https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf], 2.4 NONCLINICAL OVERVIEW [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M2_24_nonclinical-overview.pdf], “MODULE 2.6.5. PHARMACOKINETICS TABULATED SUMMARY”
Pfizer Study 185350,” Final
Report: A Tissue Distribution Study of a [3H]-Labelled Lipid
Nanoparticle-mRNA Formulation Containing ALC-0315 and ALC-0159 Following
Intramuscular Administration in Wistar Han Rat”,
is one of 21 preclinical Prizer studies involving mice, rats and rhesus
macaque non-human primates. Study No. 185350 (Sponsor Reference
ALC-NC-0552) was summarized in Pfizer’s “2.4 Nonclinical Overview” and
was separately published as a Final Report dated September 24, 2020.
Contained in that document is the following identification of the source:
Test Facility Study No. 185350 REDACTED
SPONSOR: Acuitas,
6190 Agronomy Road,
Ste. 402,
Vancouver, V6T 1Z3 Canada
Sponsor Reference No. ALC-NC-0552
This study was made up of 42 male
and 21 female Wistar Han rats. These rats were injected with 50 or 100
micrograms of BNT162b2 mRNA/LNP (lipid nanoparticle) product labelled
with a radioactive tracer material, 3H.
Then the rats were sacrificed at intervals of 0.25 hours (15 minutes); 1
hour; 2 hours; 4 hours; 8 hours; and then at 1 and 2 days.
The 100-microgram dose was associated with loss of weight and apparent toxicity in two animals. Unfortunately, the full results of the 100-microgram dose were not presented at all. [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf, p. 11.]
This is very important. The 100 microgram dose was considered too
toxic to continue to use in the experiment, so the dosage was cut in
half. 100 micrograms is the amount in the Moderna injections.
The 50 microgram dose was not safe. One female rat in the 50-microgram dose exhibited piloerection and hunched posture. [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf, p.19.]
But it did not all stay in the deltoid muscle. From the injection site
in the deltoid muscle, mRNA/ Lipid Nanoparticles appeared in blood and
plasma fifteen minutes after injection and persisted for the entire
duration of the two-day study.
On page 20 of “Final Report: A Tissue Distribution Study of a
[3H]-Labelled Lipid Nanoparticle-mRNA Formulation Containing ALC-0315
and ALC-0159 Following Intramuscular Administration in Wistar Han Rat,”
the authors note that widespread distribution to “most tissues” occurs
by the time of first analysis at 15 minutes after injection.
There was greater accumulation in blood when compared to plasma, and
males generally had higher concentrations than females with lower blood
to plasma ratios. No explanation for these differences was offered.
The major tissues that contained the drug concentration, aside from muscle at the injection site, were identified as being the liver, spleen, adrenal glands, and ovaries. The drug persisted in tissues throughout the duration of the study. The meaning and potential implications of the persistence in tissues was not addressed. [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf, p. 21.]
Top: highest mean concentrations. Bottom: equivalent % dose.
The next two tables present the overall tissue distribution data from
this study. It is reasonable to conclude, thus, that BNT162b2 is
distributed throughout the body and persists for at least two days, the
duration of the study. [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf,
pp. 7-8.] Tissue specimens were harvested but, unfortunately, no
microscopic analysis of these specimens is presented at all, so
potential damage to various organs was not evaluated.
A separate pharmacokinetic study, “PF-07302048,” looked at the persistence of the LNP (lipid nanoparticle) transport vessel with a test mRNA inside consisting of LNP coating wrapped around Luciferase mRNA, Figure 2.4.3-1 below. [“R&D STUDY REPORT No. R-20-0072 – EXPRESSION OF LUCIFERASE-ENCODING MODRNA AFTER I.M. APPLICATION OF GMPREADY ACUITAS LIPID NANOPARTICLE FORMULATION”, https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_R-20-0072.pdf.]
The object of this study was to follow the LNP vessel in plasma and liver, and then measure transcription of mRNA inside target organs to validate the delivery model using the bioluminescent properties of Luciferase to identify transcription of the mRNA in target tissues. [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_R-20-0072.pdfFrom this study, we learn that the two measured components of the lipid
nanoparticle coating, ALC-0315 [(4-hydroxybutyl) azanediyl]di(hexane-6,
1-diyl) bis (2-hexyldecanooate)] and ALC-0159 (2-[2-(polyethylene
glycol)-2000]-N, N-ditetradecylacetamide) are detectable in plasma after
300 hours – that is to say, 12.5 days – which fact raises the issue of
how long the contents of the LNP vessel with the mRNA inside persists,
and what the implications are of prolonged occupation of host cells by
this material. In this study, the BNT162b2 was injected intravenously,
accelerating the dissemination of drug. [2.4 NONCLINICAL OVERVIEW, https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M2_24_nonclinical-overview.pdf, p.16.]
Figure 1: From R&D STUDY REPORT No. R-20-0072 – EXPRESSION OF
LUCIFERASE-ENCODING MODRNA AFTER I.M. APPLICATION OF GMPREADY ACUITAS
LIPID NANOPARTICLE FORMULATION.
This study of the biodistribution of the LNP coating containing
Luciferase mRNA found that not only was the mRNA transcribed, but the
LNP “vessel” components ALC-0315 and ALC-0159 were retained in the liver
and in the plasma for at least 12.5 days. The fate of the Luciferase
mRNA was not discussed.
With respect to degradation of the mRNA component, we learn from “2.4 Nonclinical Overview” that Pfizer/Acuitas did not study at all the degradation of the synthetic mRNA in BNT162b2. Similarly, there was no analysis by Pfizer of protein products from BNT162b2 provided. [https://www.phmpt.org/wp-content/uploads/2022/03/125742_S1_M2_24_nonclinical-overview.pdf, p.20.]
Liver, Spleen, Adrenal glands and Ovaries take up increasing
amounts of drug compared with other organs as drug is transported from
the injection site by blood and plasma. These data were generated during
the 48 hours after injection and these four organs were still
accumulating the transferred drug as the experiment ended. Looking at
the tissue concentration shown on the y axis, there is 165 microgram
lipid equivalent/g drug remaining at the injection site compared with 24
microgram lipid equivalent/g in the liver. This indicates that there
may be continued transport from the injection site by blood and plasma
well beyond 48 hours when the last animals were sacrificed.
The remaining plots show patterns of drug distribution by blood and
plasma and accumulation in organs. Page 1 lists the table of values
following injection of radioactive labeling of the LNP component of
BNT162b2. Pages 2-16 are plots of drug in Adrenal glands, Bone marrow,
Brain, Heart, Kidneys, Liver, Lung, Lymph nodes mandibular and
mesenteric, Ovaries, Spleen, Thyroid, Blood and Plasma, Injection site,
mandibular lymph nodes vs. mesenteric, and organs with greatest
concentrations of the drug.
BNT162b2 has lipid nanoparticles that may have adverse effects on
organs and tissues from the lipid component as well as from the mRNA and
Spike proteins produced by the mRNA.
Graphical representation of the Pfizer data set allows the reader
to get a better understanding of how BNT162b2 flows from the injection
site to body organs.
For example, this chart is a plot of tissue concentration first
rising steeply at the injection site, left chart, then peaks and
declines as the organ systems accumulate concentrations of drug more
slowly early then rise over time, right chart.
The final chart on page 19 contrasts ovaries vs testes with approximately 38 times more drug concentration of drug in ovaries. More work is needed to see if there is a connection between menstrual cycle changes as have been reported by Lee, et. al. and elsewhere.
Similarly, although the data is incomplete with known outcome in only 27 of 270 pregnancy cases as reported in Pfizer document 5.3.6, the first three months of Adverse Events reporting following widespread release after an Emergency Use Authorization was given by the FDA. What data does exist is disconcerting.
Several serious questions are raised by these results:
- How long does the BNT162b2 mRNA persist in human tissues? Where does it go in the host cell? How long does it persist inside the cell? What proteins does it produce, and for how long?
- Is there any possibility that the BNT162b2 mRNA can be transcribed into DNA, then incorporate into the host genome? If this happens what are the implications?
- What are the toxicities from the lipid nanoparticle coating?
- Was Pfizer obligated to answer these questions prior to human testing?
- Doesn’t proper informed consent require answers to these questions?
Fortunately, answers to these important questions are beginning to appear:
1a. Duration of mRNA in tissues:
In a July 19, 2022, article, the essayist Joomi reviews the topic of how long BNT162 b2 containing mRNA stabilized by a synthetic nucleotide 1N-methyl pseudouridine persists in human tissues. [https://joomi.substack.com/p/were-still-being-misled-about-how?r=chkp3&s=r&utm_campaign=post&utm_medium=web]
A January 2022 human lymph node biopsy study from Stanford University found that the mRNA from both Pfizer and Moderna persists for at least two months, which was the duration of the study. [https://www.cell.com/action/showPdf?pii=S0092-8674%2822%2900076-9]
1b. Proteins produced from BNT162b2 mRNA:
Spike protein is produced after the mRNA is transcribed, and has been found in vivo for at least four months after inoculation. [https://joomi.substack.com/p/were-still-being-misled-about-how?r=chkp3&s=r&utm_campaign=post&utm_medium=web]
Proteins transcribed from the mRNA have not been completely characterized yet. SARS-CoV-2-like Spike protein has been identified as long as four months after inoculation with LNP/mRNA in human exosomes. Toxicity of Spike protein has been described and is reviewed in the essay “We’re still being misled about how long the mRNA vaccines last in the body.” [https://joomi.substack.com/p/were-still-being-misled-about-how?r=chkp3&s=r&utm_campaign=post&utm_medium=web]
2. What is the fate of BNT162b2 mRNA?
We were informed that “RNA is required for protein synthesis, does not integrate into the genome, is transiently expressed, and is metabolized and is eliminated by the body’s natural mechanisms and, therefore is considered safe.” [Alberer, M. et al. Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomized, prospective, first-in-human phase 1 clinical trial. Lancet 90, 1511-1520 (2017).] [Sahin, U. e al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature 547, 222-226 (2017).]
However, Alden, et. al., reporting in Current Issues in Molecular Biology 2022, 44, 1115-1126, found BNT162b2 mRNA is reverse transcribed into host DNA beginning six hours after contact with BNT162b2:
“In the BNT162b2 toxicity report, no genotoxicity nor carcinogenicity studies have been provided. Our study shows that BNT162b2 can be reverse transcribed to DNA in liver cell line Huh7, and this may give rise to the concern if BNT162b2-derived DNA may be integrated into the host genome and affect the integrity of genomic DNA, which may potentially mediate genotoxic side effects. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination.” [https://www.mdpi.com/1467-3045/44/3/73/htmThis study did not identify DNA transcribed from BNT162b2 mRNA in the host genome following transcription.
However, Zhang et. al., working at Massachusetts Institute of Technology, demonstrated fragments of SARS-CoV-2 mRNA integrated in host DNA in “Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues,” published in 2021 in PNAS, vol. 118, no. 21:
“We show here that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of the infected cell and be expressed as chimeric transcripts fusing viral with cellular sequences. Importantly, such chimeric transcripts are detected in patient-derived tissues.” [https://www.pnas.org/doi/10.1073/pnas.2105968118]
So, scientists are getting close to knowing whether BNT162b2, with its synthetic mRNA, is translated into host DNA and is now a permanent part of human genetic material. If so, the next step is to determine what the implications are.
3. What are the toxicities from the lipid nanoparticle coating?
More research is required to understand the implications of LNP concentration in various organ tissues. It is thought that the PEG component (the polyethylene glycol that coats the LNP) is responsible for anaphylaxis, an often rapid-onset major physiologic event that requires emergency treatment.
4. Was Pfizer obligated to answer these questions prior to human testing?
5. Doesn’t proper informed consent require answers to these questions?
The answers to questions 4 and 5 are “yes,” and the reasons should be obvious now. Basic information about functioning of this mRNA product, BNT162b2, was not known at the time of mass inoculation; and, therefore, a proper risk, benefits and complications discussion was compromised by lack of information. Informed consent is not possible in such a situation.
In conclusion, many negatively consequential shortcuts were made in the development of BNT162b2.
Many omissions in basic research evaluation of BNT162b2 were kept hidden, and there was outright misinformation regarding some of the work that was done.
Assumptions rather than actual research to determine where BNT162b2 goes, what it does, and how long it lasts were made that proved to be false and constitute intentional mis/dis/mal information. We were told that the prodrug, BNT162b2, consisting of a lipid nanoparticle coating of synthetic messenger ribonucleic acid (modRNA), would be deposited in muscle tissue at the injection site and would be migrate to local lymphatics prior to rapid degradation producing Spike antigens for a limited period of time that would produce a desired immune response.
However, Pfizer in its very early Phase 1 trial with mice, rats, and rhesus non-human primates learned that the LNP/mRNA is rapidly disseminated throughout the body and remained in tissues for as long as it was studied, 48 hours for BNT162b2 and 12.5 days for the LNP/Luciferase mRNA test product.
No effort was expended to determine what proteins are produced by the modRNA, what their physiological actions are and how long they are produced as well as what toxicities and adverse events might be anticipated with widespread usage of the LNP/mRNA prodrug.
FOIA requests for internal documents from federal health care agencies, independent review board members, approximately 140 clinical investigators and Pfizer personnel should be made.
Billions of doses were administered to billions of p
eople. The scale of this potentially massive medical misstep is large.
Ten months to develop novel gene therapy for a novel virus is well short of the five to 10 years usually required to develop, test and refine such a product. After billions of doses have been given to children and adults around the world, possibly altering the course of human evolution, the public is now seeing the unfortunate consequences of cutting corners.
This Report was written exclusively for DailyClout by the Members of the War Room / DailyClout Pfizer Documents Research Volunteers.
It should not be copied or republished without permission from DailyClout or a full credit and link to DailyClout.io
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