Internet of Bodies: Using CRISPR gene editing to electrically connect with and control humanity

By Naren Bhokisham


The article below, from the journal Bioengineering, concludes, “similar to how DNA based vaccines are being electroporated into the human body to fight Covid-19, we may expect that electrogenetic promoter circuits will be inserted into human cells to open a new modality of bioelectronic signaling.”

As Patrick Wood of Technocracy.News points out, the ultimate hacking of the human body will be “electrogenetics,” where human DNA can be selectively switched on and off by electronic signals.

Just like Internet of Things (IoT), the Internet of Bodies (IoB) refers to access and control of the human body via the internet. Here, we detail how CRISPR can be used to electrically connect with the genome and as a proof of concept display control over transcriptional informational networks inside E. coli and Salmonella.

Technology has played a transformative role in our lives and its impact on human health is never felt more than in the current times of the Covid-19 global pandemic.

In this scenario, development of autonomous health sensing and actuating systems, also referred to as closed loop systems that ‘sense’ and ‘act’ towards a biological condition (Kovatchev et al., 2009; Berényi et al., 2012), can play a critical role in addressing health crises of the future. Successful adoption of electronic closed loop human health systems is dependent on the development of new methods for biological actuation which has so far been limited to the century old neural stimulation and optogenetics.

Recent advances in the field of biological actuation stems from synthetic biology where our group and others have reported gene circuits that respond to electric signals with expression of specific gene of interests (Weber et al., 2008; Tschirhart et al., 2017; Krawczyk et al., 2020). In a prior publication, our group had detailed a redox-based bacterial promoter SoxS that responds to specific electrochemical signals that can be generated via an external electrode.

Using this promoter, specific transgenes of interests can be expressed in bacteria in response to programmed electric stimuli. In this work, we have taken the next logical leap for this technology, that is, using electric signals to connect and control transcriptional networks in the genome of the cells (Bhokisham et al., 2020).

To aid in our pursuit, we exploited the CRISPR technology that provides the means to target any specific target in the genome. Specifically, we used the dCas9 based transcriptional activator to electrically activate and repress select genes of interests.

Firstly, we integrated the CRISPR system with the SoxR based electro responsive promoter, optimized various components involved in the CRISPR system to make a tunable and inducible system. In this way, using CRISPR we electrically activated LasI, an autoinducer-1 (AI-1) synthase resulting in generation of AI-1, a quorum sensing mediator (Fig. 2 and 3).

Later, we repurposed the CRISPR activator to simultaneously repress select genes as well. Since the electrochemical stimuli that drives the  SoxS promoter also induces oxidative stress, bacterial cells activate intrinsic stress defense responses to attenuate the electrical stimuli. We used the repurposed CRISPR activator to repress the activation of oxidative stress defenses in E. coli and S. enterica, thus leading to enhanced output from the electrical stimuli responsive promoter (Fig 4).

When placed in the context of the complex spatio-temporal signal gradients at the bioelectronic interface, cells with repressed oxidative stress defenses displayed more aligned responses in relation to the external signal gradients (Fig. 5).

This concept of silencing certain elements in the genome in order to maintain better congruence with external environments is nature inspired and found in embryogenesis and yeast as well (Yu et al., 2008; Paulsen et al.,2011).

Read the entire story at Bioengineering.








Personhood of a Transhuman and the Data Dilemma

by Gourav Krishna Nandi, Montana State University - Bozeman, MT


{An interesting 2014 article on what might constitute personhood in a transhuman- ED}

[“Data” refers to the anthropomorphized android from Star Trek]

Abstract

Personhood is often thought to be a characteristic possessed by those who can make decisions, have moral worth and responsibilities, and can participate in civil and political rights. Are these attributes exclusive to the naturally born and naturally maintained humans? If we, in the foreseeable future, are to adapt to the assimilation of individuals with technological enhancements in society, how should we regard the personhood of such enhanced sentient beings? In this paper, I use Hume's distinction between an idea and a belief to analyze our differences in the perception of personhood in a naturally born human and a transhuman. Using the instance of Julian Savulescu’s intelligent and independent observer and Gene Roddenberry’s android character Data, I argue that personhood is an evolving idea that does not depend on strict social constraints, but is similar to the mathematical definition of infinity, an abstract approximation.


Introduction

This paper explores the notion of anthropocentric bias against a transhuman individual

As neuro-informatics and cognitive sciences continue to flourish and impact the average citizen, the analysis of new technology driven social standards is paramount. I focus on a contemporary issue concerning personhood as a set of societal beliefs that would play such a role, if we are, in the foreseeable future, to adapt to a transhuman society.  At the outset, the paper analyzes the classical attributes of personhood from the lens of ideas and beliefs proposed by David Hume. Owing to the scope of this work, I limit the definition of personhood to its empirical association with the existence of the human, where personhood is an elementary entity that differentiates a human from a non-human; hence, personhood is inseparable from the human. The existence of a human implies the existence of personhood in them. The contrapositive states, if an individual does not possess personhood, they cannot be a human.  Furthermore, considering the limits, I concentrate on how transhumanism fits.

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into human society. In other words, can we consider a transhuman to be a human-individual who possesses personhood? How would technology affect such an idea? In an attempt to answer this, I contrast the separation of the human and the natural, from an oriental perspective proposed by Ryuichi Ida in his essay “Should we Improve Human Nature? An Interrogation from an Asian Perspective.”4    Lastly, I examine a concrete instance of what it means to be a human by using Gene Roddenberry’s android character Data from Star Trek: The Next Generation  to argue that being human and possessing personhood is an intangible idea, a mathematically and materialistically unreachable quantity, which is founded on the conceptions laid down by social constraints.5

 

2. Of Beliefs and Ideas:


According to David Hume, the belief of a concept is a subset of the idea of the concept itself.6 Every aspect of a belief is constrained in the set of ideas. 7  Mathematically, this results in the possible existence of the certain properties of a concept in which we can conceive and not believe. Hume further hypothesizes that the notion of both our ideas and our beliefs as molded by our experiences is empirically

4.  Ida, Ryuichi. Should we Improve Human Nature? An Interrogatio n from an Asian Perspective., Savulescu, Julian; Bostrom, Nick, eds. Human  Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

5.  Roddenberry, Gene. Star Trek: The Next Generation.

6.  “The idea of an object is an essential part of the belief of it, but not the whole.” Sec. vii Of the Nature of the Idea or Belief.  A Treatise of Human Nature.

7.  “We conceive many things, which we do not believe.” Sec. vii Of the Nature of the Idea or Belief. A Treatise of Human Nature.

 
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axiomatic.8   An idea of a concept is an immediate result of the sensory experiences of the world and its possible logical consequences, whereas, the belief  of a certain idea is dependent on the objective laws that the world is subjected to, in accordance to our senses. Hume provides the examples of a companion proposing the events concerning the death of Caesar in his bed, and mercury being heavier than gold.9   According to the proposed conjecture, the idea of Caesar’s death on his bed is conceivable through our sensory inputs, but the experience of the world with the historical evidence suggests otherwise.10  Caesar’s death on his bed is thus merely an idea , owing to the definition of death, a bed and our acquaintance with Caesar. I dismiss it as a belief   because history disproves it.

To equate this characteristic to the idea of transhumanism, I perform an empirical analysis. Let us begin with an example of a conception along Hume’s distinction of relations of ideas and matters of fact.11


Ideas/ Caesar’s death on his bed

Beliefs/ Caesar’s death by Brutus

 

Where does the personhood of a Transhuman lie in this venn diagram?

 

8.   Hume, D. Sec. vii  Of the Nature of the Idea or Belief.  A Treatise of Human Nature.

9.  Sec. vii Of the Nature of the Idea or Belief.

A Treatise of Human Nature. “more fusible, than lead, or mercury heavier than gold; it is evident, that notwithstanding my incredulity, I clearly understand his meaning, and form all the same ideas, which he forms ... is it possible for him to conceive any idea, which I cannot conceive; nor conjoin any, which I cannot conjoin.”

10.   Julius Caesar (100 BCE - 44 BCE) was assassinated in the Roman senate

11.   Hume, D. Sec. vii Of the Nature of the Idea or Belief.  A Treatise of Human Nature.


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In the Enquiry (1748), Hume states that all ideas are derived from their impressions, which he maintains are the results of sensations.12  What I deduce from experience are therefore copies of my sensations. He reasons that even the basic axioms require oneself to possess knowledge which are the results of the accumulation of sense experiences, impressions, that cannot be exclusively deduced by reason.13   The idea of a green grass-blade, for an instance, consists of several components, all of which may be reduced to the senses. The perception of the color of the grass-blade is dependent on my visual senses. The visible light waves, consisting of various wavelengths reflect from the blade. The color that I perceive as green is the result of the absorption of all other wavelengths by the grass-blade. The shape of the blade is subjected to my touch senses. As such, the idea of a grass-blade is dependent on the conception of its various components. The existence of the grass blade in my mind is what Hume calls an idea.14   The components of the conception of the blade are constant in me as a result of previous experiences. However, the capability to stretch the idea of the grass blade in accordance to my conceptions is what I further contemplate, as the idea of personhood and its relation to the concept of transhumanism. The belief of the grass, on the other hand, includes just the possibility of the occurrence of the idea.  For instance, my brain has noticed in the past, the presence of snow on a grass-blade. But, it never contemplates the existence of a white grass-blade, for it is in the domain of an idea and not a belief. The green-ness of the blade is a component of its concept, and I

 

12.  Hume, D.An Enquiry Concerning the Principles of Morals.

13.   Hume, D. Sec. vii Of the Nature of the Idea or Belief.  A Treatise of Human Nature.

14.  Hume, D. Sec. vii  Of the Nature of the Idea or Belief.  A Treatise of Human Nature.

 

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argue that such contemplation of notion of a white grass blade is similar to the concept of a human transhuman, an individual who is transhuman despite possessing the properties of personhood. Let us contemplate the accepted notions of being a human. Humans are born naturally; they have naturally endowed characteristics, which a transhuman does not possess. Hence, I have a socially held belief on whom to assign the “human” tag. Transhumanism underscores the idea of surpassing the natural order, in order to improve the physical and the mental faculty of the human.15   In the next chapter, I use the analogy of Hume’s empirical propositions to classify physical enhancements and broadly the notion of personhood, as an approximation.16

 

2.1 Ryuichi Ida’s concept review

 

It might be assumed as an axiom, under the constraint of our technological and sociological progress, that a human becomes a transhuman only after the application of enhancements, which would not have been present without the existence of present technology.

Ryuichi Ida asserts that the concept of enhancements that pertains to physical and mental enhancements are artificial; a nano-chip inserted into the brain to increase


15.  I describe the natural order as is done by Ida: enhancing the individual in a way that wouldnot have been possible without the humans.

16.  Approximation is equivalent to limiting value in calculus. I use the word to attribute the abilityof, say ‘n’ to reach a value ‘b’. When we state that n is an approximation to the value b, it impliesthat n limits toward the value of b, but never reaches b. Mathematically, n ~  b, but n not = b.

 

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memory and to aid in extensive learning can provide an instance in this regard.17   The existence of the humans is paramount to the existence of the nano-chip. The nano-chip needed the humans to be in the current state of technology. According to Ida, the enhancement using the nano-chip is not natural, i.e, had the humans been absent from the chain of events, the chip would never have existed. However, this stance does not affirm that the existence of the humans is unnatural.

Now, every mention of an improvement in the physical and mental capabilities of a human underscores an artificial enhancement. Ida asserts there is a difference between natural enhancements and artificial enhancements of an individual. He provides an objective illustration: A candidate studying every day for a demanding examination and being rewarded with the highest grade can be termed as the realization of the person using their naturally given capabilities. The mental enhancement that results from a continuous practice using the natural endowments of a person is what, according to the Ida, constitutes the oriental definition of a natural enhancement. However, he opposes the view, where an examinee uses genetic enhancement to improve their performance in the examination. Such a modification, according to Ida, is artificial and accounts for the “control and management of nature through knowledge and technology.”18    I may conclude that Ida’s position implies that every enhancement that is possible due to the presence of the modern humans and

 

17.  Ida, Ryuichi. Should we Improve Human Nature? An Interrogation from an Asian Perspective.

Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

18.   Ida, Ryuichi. Should we Improve Human Nature? An Interrogation from an Asian Perspective.

Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

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their technological growth is termed as unnatural. Here, the usage of the word “modern” is important, as the enhancements caused due to pre-historic agricultural and urban settlements are considered by Ida as natural.19

 

3. Enhancements as beliefs and concepts

 

Despite Ida’s perception of technology as artificial, he maintains that the humans are fundamentally natural. However, the way the humans have used the natural resources during their evolution to develop technology has separated them from nature, and is thus, unnatural. As such, transhumans can exist if only we develop artificial enhancements. Such individuals cannot be termed as natural and therefore personhood cannot be associated with a transhuman. In the Venn diagram of ideas and beliefs, Ida would place the personhood of a transhuman outside the domain of beliefs.  Humans are thought to have a natural order, and the enhancements acts as a deviation from the natural to create a transhuman is unnatural.

 

3.1 Savulescu’s independent observer

 

Extending Ida’s premise of the natural human, I state two possible attributes of being human: it is an attainable state of existence or it is a mathematical state of approximation.20  If the notion of personhood an intangible concept, like infinity, personhood can be approximated to, but never reached physically. Whereas, if it is an

 

19.  Ida considers agriculture, which involves the cultivation of the land and the manipulation of the

natural order in the land ecosystem. His concerns begins with technology. I consider, in a later section, the definition of technology. Should any tool making be termed as technology, or is it just the modern improvements? In other words, how different is the building of a chisel to that of a computer?

20.  I use the terms being human and personhood interchangeably

 

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attainable state, there is a set of clauses, obtaining which, an individual can possess personhood. Moreover, if human nature is a mathematical approximation of propositions, individuals whom I consider transhumans in the contemporary society, may be defined as humans in a transhumanist society, for a change in the social paradigms would witness the growth of the set of beliefs. Here, I reason that enhancement cannot make us any more or any less human, using the view of an independent observer, a view which is against the oriental perspective as asserted by Ida.21

 

3.1.1 The Natural and the Artificial to the Independent Observer

 

The differentiation of the human and the natural underscores the separation of the two. It asserts the East Asian perspective upheld by Ida, who considers living amidst nature, but excludes the human when considering natural.22  However, the differentiation of the unnatural from the natural enhancement is a propensity that is historically evident in both the Eastern and the Western traditions, where philosophers have sought to distinguish between the natural and the human.

In an attempt to nullify this distinction, I consider Savulescu’s independent observer. Let us contemplate a hypothetical scenario where there exists an intelligent species on a different star system, who apparently, have developed warp drive and traveled to Earth to observe human activities. From the perspective of our visitor,

 

21.  Savulescu, Julian. Prejudice and Moral Status of Enhanced Beings.  Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

22.  Ida, Ryuichi. Should we Improve Human Nature? An Interrogation from an Asian Perspective.

Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

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anthropocentric values are inconsistent; their superior intelligence affirms that our technological developments and the reworking of the Earth’s surface, to them, is synonymous to our view of say, the chimpanzee using tools and displaying empathy. Savulescu terms such an observer, an independent one, who is not only devoid of my anthropocentric biases, but is also able to comprehend human intelligence. Our premise examines if the independent observer would consider our creations natural. We often attribute the same characteristic of animals using tools to the chimpanzee who uses a tool and the hummingbird who builds its nest. I reason that the association of our building of a modern city and the building of the ant-hill by the army ants to the intelligent observer is coherent and logically consistent with the premise that the observer is more intelligent than both the species. To them, without the presence of the army ants on the planet, the ant colonies and the ant-hill would never have existed, as would a city of humans without the humans. The hypothesis is also a reminder to us that our creation of advanced tools and computer technology is but a better manipulation of the natural resources available to us. The army ant uses its own armor (its natural endowment) and twigs (utilization of natural resources) to dig the soil and create the ant-hill. Similarly, we use advanced iron ore, and bricks and cement (advanced utilization of natural resources) to create buildings in a city. Evidently, to the observer, the distinction between the ants and the humans is in the advancements of tool making. As such, when we invent physical enhancements to create a transhuman, the inherent nature of the device would be termed natural to such an observer. The argument bridges the gap between the human and the natural, which in the first place existed because of our human-centric approach to the problem. The transhuman, I can


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reason, is a natural product, owing to the advanced use of the natural resources available to us.

To return to the initial argument concerning the beliefs and the ideas of a natural and an artificial enhancement, I conclude that the enhancement as a natural process is an idea for Ida, which exists as a belief to the independent observer. So far, I have concluded that the enhancements required to create a transhuman are natural; let us now explore the personhood of a transhuman. Due to the scope of this paper, I limit myself to the attribution of personhood to the transhuman individual. I assume personhood as a natural characteristic of the human individual owing to its development in us without any unnatural process. The human tag is associated with an individual who possesses personhood, as I discussed in the introduction. To analyze the possibility of a transhuman to be perceived as a human, in the following section, I study the fictional character Data from Star Trek: The Next Generation.

 

4. Data and Personhood

 

Data is an android character created by Gene Roddenberry for his popular science fiction series. The android is anthropomorphic in its appearance and functions. Data is programmed to evolve, and his goal is to become more and more human. According to Gene Roddenberry, the character was to be the closest one can be to a human without being a human.23  Nevertheless, the quintessential requirement to be a human, as mentioned above, is the possession of personhood. Data is a transhuman;

 

23.   Savulescu, Julian.  Prejudice and Moral Status of Enhanced Beings.Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

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he has capabilities, which transcends the physical and mental capacities of the average human. He is stronger, can think faster, and though made of silicon, he is able to evolve. At the outset, I shall consider Data a life form, as urged by Roddenberry.24   Besides, according the prevalent NASA’s definition of life, Data is capable to reproducing and evolving in a Darwinian approach. However, is Data a person? To answer this question, I retreat to Hume’s ideas and beliefs  to differentiate between Data’s personhood considering our social paradigms.



4.1 Beliefs and Ideas concerning transhumanism


According to Ida, Data does not possess the characteristics about the ideals of personhood, owing to his artificial birth. I shall analyze Data’s status quo as a human, despite his physical differences. Ida’s foremost appeal towards a human person is arguably an attempt to nullify the idea of unnatural improvements. In the previous two sections, we have concluded that from the view of an unbiased, independent observer, the improvements are natural, even if they include an enhancement using technology.

According to the Star Trek canon, given the right circumstances, Data acts like a human.25  Alan Turing pioneered the idea of a machine imitating a human in his famous experiment where the machine is able to fool the human into making him think that the machine was a human. He delved into the idea of a thinking machine. Data’s nature is similar to the dichotomy I analyzed in the first section. Firstly, he is an android. He is made of silicon chips rather than flesh and blood. He lacks the accepted definition of a human, but Roddenberry came up with the idea of an emotion chip, a device when

 

24.  Roddenberry, Gene. “Datalore”.  Star Trek: The Next Generation, Paramount, 1987. Web. 20 Apr. 2013.

25.  Roddenberry, Gene.  Star Trek: The Next Generation.

 

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placed in Data’s circuits makes him “experience” human emotions.26   Often, Data is incapable of handling the emotions that he is subjected to due to their mathematical complexity, but the fact that he can experience a new emotion that is not controlled by the machine acts for the argument of assigning personhood with Data. He is able to think, to sacrifice, to love, to feel pain and even get confused with the emotion chip. As such, with the device implanted in Data’s body transforms the android into an individual having personhood. But should such an individual be called a human being? It can be argued that Data acts as a nonhuman with the subtraction of a certain chemical in their brain, but I reason that the lack of certain chemicals in the human brain can render a naturally born human, a non-person. As such, the criteria I discussed about Data’s personhood is consistent with humans as well; the fact that it’s an emotion chip that prevents Data from being a human is compatible logically.

 

4.2 Personhood as an approximation

 

As such, I can reason that the concept of transhuman is just an idea of an extended human. It’s a trans-person, someone more capable in some respect and less capable in other aspects of an individual socially accepted as a human. This is especially true for those who claim that being human cannot be reduced to a set of specific clauses; it is an intangible property.

 At the beginning of the paper, I limited myself to the empirical association of personhood to being human. Every individual who is a human possesses personhood. This condition does not necessarily imply that every possessor of personhood is a human. Rather, anyone not having personhood devoid themselves off the idea of being

 

26.  Roddenberry, Gene. “Generations”. Star Trek: The Next Generation, Paramount, 1987. Web. 20 Apr. 2013.

 

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a human. Data, on the other hand, as I concluded, has personhood. He shows every characteristic that would tag him the notion of being a human. As such, being human has a necessary condition in personhood. Since, I have concluded that personhood is limited mostly by my acceptance of ideas into beliefs, I reason, there are no set of reducible clauses that would define the personhood of an individual.

 

5.  Conclusion

 

The essay began with an inspiration in popular science fiction, and how the ideas relating to personhood apply to Data, the anthropomorphized android from Star Trek.27

 

 I borrow the idea of mathematical infinity to reflect upon his goal. Infinity, for all its uses in

calculus, has never been defined. It is the abstract notion of a number which is larger than every other number imagined by the human mind. From Hume’s empirical point of view, infinity is not in the domain of a belief, for it’s incoherent with human experience. The only way I can define infinity is by limiting myself to the idea.  As an instance a statement in symbolic mathematics,

 

limn  --> infinity 1/ n = 0

implies that the value of 1/ n is 0, when n tends to infinity. Here, n is an integer; it never actually reaches infinity for an integer is presumed to be in the domain of a belief, it has an empirical existence in the human mind. As such, despite the immensity of its value, n always represents a number, which excludes the possibility of being infinite. The above expression, thus is concerned about the value that 1/n obtains, as n becomes larger,

 

27.  The choice to include Data ahead of C3PO or other androids is based on Data’s goal throughout the Star Trek series:  to become as close to being a human without becoming a human.

 

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which is 0.  In other words, the statement doesn’t prove the equivalence of the value of

n to infinity but of the equivalence of the value of 1/n to 0.

 

The analysis of Data’s personhood has synonymity in the definition of his goal: to become human.

 

Ideas/ Personhood of Data

Beliefs/ Accepted notion of personhood

 

The figure points out two constraints:

•to be a member of the set of beliefs, a concept has to be a set of ideas (Hume’s definition).

•the set of beliefs and the set of ideas are not necessarily equal. In other words, there are ideas which may not be beliefs.

Data’s personhood would be recognized by the social constraints as I learn that from an independent observer’s position, it’s our limitations that would not confer personhood on Data in the present society. I have drawn the set of beliefs in dotted lines to represent an ever changing set of the societal paradigms and our acceptance of who is a human; a notion that, in time, will broaden enough to include the personhood of Data. Personhood, as such, is alike infinity which is abstract, on its own, but tends to function when applied to a physical object to which I am acquainted. As I, from an unbiased approach define the relationship of Data and the notion of being human, I

 

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observe an equivalence between Data and a human, as he evolves towards his personhood.28

 

Mathematically,

 

limData --> Personhood Data = Human”


28.  Savulescu, Julian. Prejudice and Moral Status of Enhanced Beings.  Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

PAGE 17:  REFERENCES

Hume, D. Sec. vii

Of the Nature of the Idea or Belief. A Treatise of Human Nature.

 

Hume, D. Sec. vii

Of the Nature of the Idea or Belief. A Treatise of Human Nature.

 

Hume, D., An Enquiry Concerning the Principles of Morals.

 

Hume, D. Sec. vii

Of the Nature of the Idea or Belief. A Treatise of Human Nature

 

.•Ida, Ryuichi. Should we Improve Human Nature? An Interrogation from an Asian Perspective.

Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

Ida, Ryuichi. Should we Improve Human Nature? An Interrogation from an Asian Perspective.

Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

Manzo, Silvia. "Francis Bacon: Freedom, Authority and Science."  British Journal for the History of Philosophy  14.2 (2006): 245-73. ProQuest.Web. 29 Apr. 2013.

 

Morris, John. "Pattern Recognition in Descartes' Automata."  Isis  60 (1969): 451-60. ProQuest.

Web. 29 Apr. 2013.

Rozemond, Marleen. "Descartes's Case for Dualism."  Journal of the History of Philosophy

 33.1 (1995): 29-63.  ProQuest. Web. 29 Apr. 2013.

Roddenberry, Gene.  Star Trek: The Next Generation.

Savulescu, Julian. Prejudice and Moral Status of Enhanced Beings. Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

 

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Savulescu, Julian. Prejudice and Moral Status of Enhanced Beings. Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

Roddenberry, Gene. Star Trek: The Next Generation.

Savulescu, Julian. Prejudice and Moral Status of Enhanced Beings.  Savulescu, Julian; Bostrom, Nick, eds. Human Enhancement. Oxford; New York: Oxford University Press, 2009: 59-70.

Roddenberry, Gene. “Datalore”. Star Trek: The Next Generation. Paramount, 1987. Web. 20 Apr. 2013.

Roddenberry, Gene. “Generations”. Star Trek: The Next Generation, Paramount, 1987. Web. 20 Apr. 2013.

Taub, Liba. Ptolemy's Universe: The Natural Philosophical and Ethical Foundations of Ptolemy's Astronomy., 1993. ProQuest. Web. 28 Apr. 2013.

Xenophanes, Clement of Alexandria, Book V. 110.


FOOTNOTES:

1.  I generalize the notion of a transhuman, where an  individual with any form of enhancement that enables them to better their functioning, physically or mentally, is called a transhuman.

Also, considering that our understanding is materialized by perception, I consider bias to be an a-priori tautology. We perceive matter, as it were, through the senses. In other words, spatial and temporal occurrences in nature trigger the stimulus that engender into (engender into?) the perceptions we undergo. What we perceive as physical objects are the result of the reactions due to events that cause the materialization of the physical objects.

2.  “Personhood” is often taken to have a very special and specific meaning in philosophy —those things with personhood have moral latency; that is, they are objects of moral concern, are worthy of being cared about, have rights, have responsibilities, etc. Persons often are thought to be those things that can make decisions, or, at the very least, are things that we make decisions about legally and morally, because they are important and worthy of moral judgment.

3.  Personhood => Human

               not (Human) => not(Personhood)





[Note:  Amazing -- another plunge into philosophy -- this time by a transhumanist using a modern philosopher (Hume-the-empiricist and utilitarian) and a special mathematical formula to justify Posthuman “Personhood” -- specifically, the “personhood” of Data, the Star Trek android!  If ever there was an example of someone using the subject matter and method of one field (math) while trying to analyze the subject matter of a different field (philosophical anthropology, or how to define “a human being”) it is this article -- and apparently he doesn’t even know that he is violating the division and methods of the “sciences”!  (Same weird phenomenon with engineers, physicists and mathematicians doing human genetics in biology!).  E.g., you can’t study math with a microscope, and you don’t have a bus driver perform brain surgery!  Another sizzling failure of NanoBioInfoCogno.  (Whoever thought that up?!).

Not to mention that all “modern” philosophies (including utilitarian bioethics) are riddled with problems that real philosophers are fully aware of, and Hume is no exception -- especially the theoretically devastating “mind/body split”.   Additionally, David Hume (1711-1776):

“ ... questioned common notions of personal identity, and argued that there is no permanent “self” that continues over time. He dismissed standard accounts of causality and argued that our conceptions of cause-effect relations are grounded in habits of thinking, rather than in the perception of causal forces in the external world itself.  ...  In the philosophy of religion, he argued that it is unreasonable to believe testimonies of alleged miraculous events, and he hints, accordingly, that we should reject religions that are founded on miracle testimonies. ...  In moral theory, against the common view that God plays an important role in the creation and reinforcement of moral values, he offered one of the first purely secular moral theories, which grounded morality in the pleasing and useful consequences that result from our actions. He introduced the term “utility” into our moral vocabulary, and his theory is the immediate forerunner to the classic utilitarian views of Jeremy Bentham and John Stuart Mill.”  Internet Encyclopedia of Philosophy, at:  http://www.iep.utm.edu/hume/

But this writer is apparently clueless as to the “cons” of Humean philosophy or of utilitarian bioethics which render irrelevant this writer’s wished-for conclusion below --including the “cons” of transhumanist/bioethicist student of Peter Singer, Savulescu.  In a real philosophical analysis it is required to acknowledge both the “pros” and the “cons” of any particular philosophical position and respond to those “cons” before adopting that philosophical position as your own -- otherwise your opponent will gladly hurl them at you.  You can’t just pick and choose bits and pieces of a particular philosophical tradition that please you and gets you where you want to go, and ignore the bits and pieces that you don’t want.

And while some “personhood” standards and definitions of "a human being" are simply matters of "evolving" social constructions (such as that proposed in the following article), not all “personhood” standards are.  Indeed, some are inherently empirically grounded in our objective knowledge of human beings -- whole human beings, that is.  [See Irving, “Philosophical and scientific expertise:  An evaluation of the arguments on ‘personhood’”, Linacre Quarterly February 1993, 60:1:18-46, at:  http://www.lifeissues.net/writers/irv/irv_04person1.html;   also "What is 'bioethics'?" (June 3, 2000), at:  http://www.lifeissues.net/writers/irv/irv_36whatisbioethics01.html].

I do wonder what kind of “academic” organization would even want to post the following hypothetical space-alien perspective of the "independent observer" using symbolic mathematical/utilitarian philosophical/bioethical  “analysis” to argue for the possible social-constructed “personhood” for posthumans based on infinity.   But I’m sure NBIC and WTEC -- and Roddenberry -- will love it.  PS -- if you can’t follow the “logic” of the following article, or get dizzy, it’s not you.  The article first appeared here. --  DNI]

 







IEET’s George Dvorsky offers course on Introduction to Transhumanism

{An interesting 2014 article demonstrating an artificially stimulated interest in transhumanism - ED].


by Institute for “Ethics” and Emerging Technologies (IEET)
(Co-founded by transhumanists James Hughes and Oxford don Nick Bostrom)

IEET’s George Dvorsky offers course on Introduction to Transhumanism

George Dvorsky, prominent futurist, writer on ethics and technology and Chairman of the IEET Board of Directors, is offering his:  Introduction to Transhumanism course during May, from May 1st to May 31st, 2014.

This course introduces the philosophy and socio-cultural movement that is transhumanism. We will survey its core ideas, history, technological requirements, potential manifestations, and ethical implications. Topics to be discussed will include the various ways humans have tried to enhance themselves throughout history, the political and social aspects of transhumanism, the technologies required to enhance humans (including cybernetics, pharmaceuticals, genetics, and nanotechnology), and the various ways humans may choose to use these technologies to modify and augment their capacities (including radical life extension, intelligence augmentation, and mind uploading). Along the way we will discuss social and ethical problems that might be posed by human enhancement.

Schedule and readings: Specific reading and discussion goals are set for each week, and students can proceed at their own pace. There are no live events planned. An assortment of resources will be used, including academic papers, online presentations, instructional videos, and popular articles. Everything about the course and all readings are provided within the PSA Moodle website. Course lectures, links to websites, and forums for discussions with the instructor and students are included in the Moodle website classroom. Visit the class anytime to contribute your posts and receive George Dvorsky’s replies in discussion forums. There is nothing “live” you can miss – log in and participate anytime day or night, 24/7, throughout May.

Ask George about this course by tweeting to him at twitter.com/dvorskyor posting on his facebook wall at www.facebook.com/gdvorsky

Canadian futurist, science writer, and ethicist George Dvorsky has written and spoken extensively about the impacts of cutting-edge science and technology—particularly as they pertain to the improvement of human performance and experience. George is a contributing editor at io9 where he writes about science, culture, and futurism. A founding member of the Institute for Ethics and Emerging Technologies, he is its Chair of the Board and the founder and program director for its Rights of Non-Human Persons program. In addition, George is the co-founder and president of the Toronto Transhumanist Association and has served on the Board of Directors for Humanity+ for two terms. His work has been featured in such publications as The Guardian, the BBC, CBC, Forbes, the New York Times, Slate, Radio Free Europe, and al-Jazeera. He is also an avid CrossFitter, an ancestral health enthusiast, and an accomplished music performer, composer, and recording engineer.




[Note:  Couldn’t be more “in their own words” and “in your face”.  Let’s remember that bioethics founder Art Caplan is on the IEET board of trustees, so we already know which “ethics” they use, including utilitarian’s “for the greater good” and the libertine bioethics principle of absolute “autonomy”:  http://ieet.org/index.php/IEET/bio/caplan/;  also,

http://ieet.org/index.php/IEET/category/C46.   And of course, see a good upfront description of transhumanism/futurism/posthumanism in the recent articles by transhumanists, at:  http://wavism.net/principles/what-is-social-futurism/, and at  http://www.psychologytoday.com/blog/the-transhumanistphilosopher/201404/transhumanist-explores-new-type-community (Bitcoin and all). The article first appeared here.